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ENHANCING OF METHOTREXATE ACTIVITY DURING OPTICAL BEAM IRRADIATION IN PHOTODYNAMIC THERAPY OF CANCER AND NON-CANCER DISEASES

M. Brezeanu1,* , D. M. Gazdaru2, L. Voicu1, R. Morarescu2

Affiliation

  1. National Institute for Lasers, Plasma and Radiation Physics, Laser Department, P. O. Box MG-36, Bucharest – Magurele, Romania
  2. University of Bucharest, Faculty of Physics, Department of Biophysics, P. O. Box MG-11, Bucharest – Magurele, Romania

Abstract

Photodynamic therapy (PDT) as a method used in the treatment of some types of cancer may also be used to treat some non-cancerous diseases of the skin or eye. PDT uses laser or other light sources, combined with a light sensitized drug (sometimes called a photosensitizing agent) to destroy cancer cells. Once the drug is accumulated in the tumour cells, if photons of ultraviolet and visible light (UV-VIS) are incident to them, the drug is activated and the cancer cells are destroyed. In the present work, we studied the photosensitizer properties of the cytostatic drug (methotrexate), used as photosensitizing agents, by its exposure to UV-VIS radiations. An experiment model for a possible clinical application was performed, also. Its effects were analyzed on the optical microscopic examination of the biological material used. As a result, we could observe a cytostatic activity enhancement..

Keywords

Methotrexate, Photodynamic therapy, Photosensitisers, UV-vis irradiation.

Submitted at: April 26, 2004
Accepted at: Dec. 6, 2004

Citation

M. Brezeanu, D. M. Gazdaru, L. Voicu, R. Morarescu, ENHANCING OF METHOTREXATE ACTIVITY DURING OPTICAL BEAM IRRADIATION IN PHOTODYNAMIC THERAPY OF CANCER AND NON-CANCER DISEASES, Journal of Optoelectronics and Advanced Materials Vol. 6, Iss. 4, pp. 1305-1310 (2004)