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KRAMERS-KRONIG ANALYSIS OF 5,10,1,20-TETRA-P–SULFONATO PHENYL-PORPHYRIN (TSPP) AS PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY

M. A. Calin1,* , R. M. Ion2, N. Herascu1

Affiliation

  1. National Institute of Research and Development for Optoelectronics INOE 2000, Bucharest, Romania
  2. National Institute of Research and Development for Chemistry and Petrochemistry – ICECHIM, Splaiul Independentei 202, Bucharest, Romania

Abstract

Photodynamic therapy is a local treatment modality of cancer, based on the administration of photosensitizer, which is selectively retained al tumoral level, and which after the optical radiations exposure lead to the tumoral tissue destruction. The application of the photodynamic therapy in clinical practice presents many problems. The present study aims to correlate the refraction indices of the tumoural tissue with refractive indices of photosensitizer solutions and optical radiation distribution at tumoral level. There were used diffuse reflection spectrophotometry and molecular absorption spectrophotometry for the characterization of the optical properties of certain photosensitizer and the Kramers-Kronig analysis for the determination of the refraction indices of the solutions..

Keywords

Porphyrin, Photodynamic terapy, Cancer, Photosensitizer, Diffuse reflection spectroscopy, Kramers - Kronig analysis.

Submitted at: Oct. 28, 2005
Accepted at: Nov. 24, 2005

Citation

M. A. Calin, R. M. Ion, N. Herascu, KRAMERS-KRONIG ANALYSIS OF 5,10,1,20-TETRA-P–SULFONATO PHENYL-PORPHYRIN (TSPP) AS PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY, Journal of Optoelectronics and Advanced Materials Vol. 7, Iss. 6, pp. 3155-3160 (2005)