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Polymeric biocompatible structures for controlled drug release

T. ZECHERU1,* , C. ZAHARIA1, A. SĂLĂGEANU2, C. ŢUCUREANU2, E. RUSEN1, B. MĂRCULESCU1, T. ROTARIU3, C. CINCU1

Affiliation

  1. University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Macromolecular Compounds, 149 Calea Victoriei, 010072 Bucharest, Romania
  2. National Institute of Research-Development for Microbiology and Immunology Cantacuzino, 103 Splaiul Independenţei, 050096 Bucharest, Romania
  3. Military Technical Academy of Bucharest, 81-83 Bd. George Coşbuc, 050141 Bucharest, Romania

Abstract

The purpose of using polymers in drug delivery systems is to be able to create a membrane-like barrier that would control the delivery of the active agent for an extended period. Poly (2-hydroxyethyl methacrylate) (pHEMA), when cross-linked, swells to a significant extent. Hence, it was thought necessary to determine its degree of swelling when incorporating methyl methacrylate (MMA), which is a hydrophobic monomer. The polymeric micro-beads of p(HEMA) and functionalised biopolymers of p(HEMA-co-MMA), p(HEMA-co-AA) and p(HEMA-co-MMA-co-AA) were prepared by precipitant polymerisation method. There were obtained different types of micro-polymeric beads, which were characterised by elemental analysis, measure of the degree of swelling, scanning electron microscopy (SEM), and in vitro tests. All these tests gave satisfactory results..

Keywords

Drug delivery, Swelling, Micro-polymeric beads, In vitro tests.

Submitted at: Aug. 30, 2006
Accepted at: Sept. 18, 2007

Citation

T. ZECHERU, C. ZAHARIA, A. SĂLĂGEANU, C. ŢUCUREANU, E. RUSEN, B. MĂRCULESCU, T. ROTARIU, C. CINCU, Polymeric biocompatible structures for controlled drug release, Journal of Optoelectronics and Advanced Materials Vol. 9, Iss. 9, pp. 2917-2920 (2007)