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TARGETING MAGNETIC CARRIER PARTICLES IN TUMOUR MICROVASCULATURE – A NUMERICAL STUDY

O. Rotariu1,2,* , L. E. Udrea1, N. J. C. Strachan2, V. Badescu1

Affiliation

  1. National Institute of Research and Development for Technical Physics –I.F.T., Iasi, 700050, Romania
  2. University of Aberdeen, School of Biological Sciences, Aberdeen, AB24 3UU, United Kingdom

Abstract

The delivery of anticancer agents via magnetic carrier particles is an exciting new prospect in treating cancer. The targeting of tumours situated at large distances from the surface of the human body is difficult because the magnetic force decreases rapidly with the distance from the magnets. Here numerical modelling is used to investigate physical and physiological limits that influence the focus of small magnetic particles (MPs) within the microvasculature of tumours. Methods using systems of permanent magnets were found to have a range of capture < 12 centimetres and this depends on the blood flow rate, the magnetic field, the MPs properties, the length of blood vessels and their diameters. These results indicate that this methodology is suitable for treating sub-surface cancers within the human body..

Keywords

Magnetic drug targeting, Magnetic particles, Blood flow, Capillaries, Arterioles and small arteries, Mathematical modelling..

Submitted at: July 19, 2005
Accepted at: Nov. 24, 2005

Citation

O. Rotariu, L. E. Udrea, N. J. C. Strachan, V. Badescu, TARGETING MAGNETIC CARRIER PARTICLES IN TUMOUR MICROVASCULATURE – A NUMERICAL STUDY, Journal of Optoelectronics and Advanced Materials Vol. 7, Iss. 6, pp. 3209-3218 (2005)