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The modification of phenyl – pyridine compounds under UV irradiation: FTIR investigation

F. UNGUREANU1,* , L. VOICU1, I. ANDREI1

Affiliation

  1. National Institute for Laser, Plasma and Radiation Physics, Laser Department, P.O. Box MG36, Bucharest – Magurele, Romania

Abstract

Phenyl-pyridine compounds present a high interest for Photodynamic Therapy due to their important anti-inflammatory and anti-tumor properties. In this study, two phenyl-pyridine compounds were investigated BG204 (3-amino, 9-thio [2-N-N diethylaminoethyl] acridine) and BG 1120 (4,5 bis [thio(2-N-N-diethylaminoethyl)], 9methyl 1,8-diazantracene), because they present modification during UV irradiation. In order to elucidate these modifications FTIR spectroscopy was used. BG204 and BG1120 were UV irradiated using a Xe lamp, with a power density of 11mW/cm2, for 1 hour, and 3 hours, respectively. The FTIR spectra, in the range of 4000 cm-1 – 400 cm-1, were performed by a Nicolet Magna IR 550 spectrometer. The results of the analyzed samples showed that these molecules are photo-reactive, and their therapeutic effects can be improved by UV irradiation..

Keywords

Phenyl – pyridine compounds, FTIR spectroscopy, UV irradiation.

Submitted at: Sept. 20, 2005
Accepted at: Jan. 26, 2006

Citation

F. UNGUREANU, L. VOICU, I. ANDREI, The modification of phenyl – pyridine compounds under UV irradiation: FTIR investigation, Journal of Optoelectronics and Advanced Materials Vol. 8, Iss. 1, pp. 315-318 (2006)