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Animal innoculation tests on the sintered titanium biocompatibility

C. R. ROMAN1,* , L. A. SORCOI2, I. JURCĂU3

Affiliation

  1. Iuliu Hatieganu University of Medicine and Pharmacy Cluj, 13, Emil Isac, 400023 Cluj-Napoca, Romania
  2. Tehnical University, Science and Engineering of Materials Faculty, 103-105, Muncii Avenue, 400641 Cluj-Napoca, Romania
  3. The Children Emergency Hospital, Laboratory of Animal Pathology, Cluj-Napoca, Romania

Abstract

The use of titanium and its alloys in medicine is justified by the beneficial properties it has. In order to verify the biocompatibility of the sintered titanium achieved through modern powder metallurgy methods tests of animal inocuity on sheep. Titanium powder treated by powder metallurgy specific procedures was used for this purpose. Three incisions of three cm were made in the following regions: the retroscapular area for a subcutaneous implant, the tibial diaphysis for the subperiosteal implant and the latissimus dorsi area for the intramuscular implant. Three samples of tissue relevated in the three distinct areas mentioned were subjected to histopathological tests. The metal samples and the three tissue samples of adjacent periosteal, muscular and subcutaneous tissue were immersed in liquid nitrogen for 5 minutes at – 196 °C; tissular fragments were prelevated longitudinally with the microtome to expose the interface of biological tissue – sintered Ti part..

Keywords

Titanium, Biocompatibility, Biological response: tissue-material interactions.

Submitted at: Nov. 13, 2007
Accepted at: April 4, 2008

Citation

C. R. ROMAN, L. A. SORCOI, I. JURCĂU, Animal innoculation tests on the sintered titanium biocompatibility, Journal of Optoelectronics and Advanced Materials Vol. 10, Iss. 4, pp. 965-968 (2008)