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Anticancer effects of nanometallic oxides and their ligands with photosensitizers in osteosarcoma cells

M. FAKHAR-E-ALAM1,2,3,* , K. SULTANA3, NAJEEB ABBAS2, M. ATIF4,5, O. NUR3, M. WILLANDER3, NASIR AMIN2, W. A. FAROOQ4

Affiliation

  1. Institute of Fundamental and Frontier Science , University of Electronics Science and Technology, China, 610054 Chengdu, Sichuan, China
  2. Department of Physics, GC University, Faisalabad, Pakistan
  3. Department of Science and Technology, Campus Norrköping, Linköping University, SE-60174 Norrköping, Sweden
  4. Department of Physics and Astronomy, College of Science, King Saud University Riyadh 11451, Saudi Arabia
  5. National Institute of Laser and Optronics, Nilore, Islamabad, Pakistan

Abstract

We studied the cytotoxic effects in Osteosarcoma (U2OS) cells to different nanosized metallic oxides e.g. zinc oxide nanowires (ZnO-NRs), manganese di-oxide nanowires (MnO2 NWs), ferric oxide nanoparticles (Fe2O3 NPs) individually and their complexed forms with photosensitizers photofrin®, 5-Aminolevulinic acid (5-ALA), and protoporphyrin IX (Pp IX). Cellular toxicity was assayed by cellular morphology, reactive oxygen species (ROS) detection, MTT assay under ultraviolet (UV), visible light and laser exposed conditions. Prominent cell death with above cited nanomaterials in their complexed forms with Photosensitizer was observed in labeled U2OS cells. This cell death might be due to their synergetic effect via the release of singlet oxygen species in Osteosarcoma cells showing their anticancer-cell effects..

Keywords

Osteosarcoma cell, reactive oxygen species (ROS), MTT assay, photodynamic therapy (PDT).

Submitted at: Sept. 7, 2015
Accepted at: Oct. 28, 2015

Citation

M. FAKHAR-E-ALAM, K. SULTANA, NAJEEB ABBAS, M. ATIF, O. NUR, M. WILLANDER, NASIR AMIN, W. A. FAROOQ, Anticancer effects of nanometallic oxides and their ligands with photosensitizers in osteosarcoma cells, Journal of Optoelectronics and Advanced Materials Vol. 17, Iss. 11-12, pp. 1808-1815 (2015)