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Bioimaging and photodynamic activity studies of mesoporous silica nanoparticles with incorporated photosensitizers

AI-HONG WANG1, XIAO-QIN HUANG2, RUI PU2, YAN-HUAI ZHOU2,* , HE-MING WU3,*

Affiliation

  1. Nursing college of Nanjing University of Chinens Medicine, , Nanjing, P. R. China
  2. Key Laborotory of Opto-Electronic Technology, Nanjing Normal University, Nanjing, P. R. China
  3. Institute of Stomatology, Department of Oral and Maxillofacial Surgery, Nanjing Medical University, No. 136, Hanzhong Avenue, Nanjing, P.R. China

Abstract

A multifunctional system, combining two modalities of imaging and treatment, was prepared by encapsulating hypocrellin A, a photosensitive anti-cancer drug owned fluorescence, into the mesoporous silica nanoparticles. The results showed that after incorporation inside the mesoporous silica nanoparticles, the fluorescence intensity of hypocrellin A was greatly increased and the light stability was improved accordingly. Further more, comparative study of free hypocrellin A and the incorporated one indicated that both of them can be taken up by cancer cells, but the fluorescence of the incorporated one was more obvious and stable than the free one. Besides, significant damage to such impregnated tumor cells, treated with hypocrellin A incorporated mesoporous silica nanoparticles, was observed upon irradiation with light. Above results showed that such mesoporous silica nanoparticles with incorporated hypocrellin A have great application potential in the field of fluorescence imaging based diagnose and photodynamic therapy..

Keywords

Antitumor agents, Silicon compounds, Photochemistry, Nanostructures, Hypocrelllin A.

Submitted at: Sept. 3, 2014
Accepted at: May 7, 2015

Citation

AI-HONG WANG, XIAO-QIN HUANG, RUI PU, YAN-HUAI ZHOU, HE-MING WU, Bioimaging and photodynamic activity studies of mesoporous silica nanoparticles with incorporated photosensitizers, Journal of Optoelectronics and Advanced Materials Vol. 17, Iss. 5-6, pp. 590-596 (2015)