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R. INDHU1,* , S. RADHA1, E. MANIKANDAN1, B. S. SREEJA1, RAVI NATHURAM BATHE2
- Department of ECE, SSN College of Engineering, Chennai– 603110, India
- International Advanced Research Centre for Powder Metallurgy and New Materials (ARCI), Hyderabad- 500005, India
This paper presents the fabrication of miniaturized microfluidic device based on cyclic olefin polymer for the separation of serum from blood. The characteristics and performance of the proposed micro-holes array are analyzed for its trapping of red blood cell, serum separation and cholesterol presence using FEM numerical simulation. An array of micro-holes are created on biocompatible cyclic olefin polymer using femtosecond laser ablation. A single track of experiments has been carried out to obtain the required depth of 2microns with a diameter ranging from (8-27)µm for various Fluence levels of the incident laser beam. The surface morphology is characterized using optical microscopy images. The fabricated device is tested for its characteristics in real time in a clinical laboratory. The obtained results match well with the simulation results..
Microfluidics, COP, Serum, Trapping, Laser, Ablation.
Submitted at: Nov. 12, 2018
Accepted at: April 8, 2019
R. INDHU, S. RADHA, E. MANIKANDAN, B. S. SREEJA, RAVI NATHURAM BATHE, Femtosecond laser machined miniaturized micro device for serum separation in bio-sensing applications, Journal of Optoelectronics and Advanced Materials Vol. 21, Iss. 3-4, pp. 238-243 (2019)
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