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Gelatin-hydroxyethyl cellulose magnetic microparticles as drug carriers: preparation and characterization

L. BALAITA1,* , C. A. PEPTU1, P. POSTOLACHE2, G. LISA1, M. POPA1

Affiliation

  1. “Gheorghe Asachi” Technical University of Iasi, Faculty of Chemical Engineering and Protection of the Environment, Prof.dr.docent Dimitrie Mangeron Street, 73, 700050, Iasi, Romania
  2. “Alexandru Ioan Cuza” University of Iasi, Faculty of Physics, 11 Carol I Blvd., 700506, Iasi, Romania

Abstract

The aim of this study is the preparation and characterization of magnetic polymer microparticles suitable for the treatment of certain cancer diseases. For their preparation the crosslinking method in reverse emulsion has been used, leading to an interpenetrated network based on both natural polymers gelatin and hydroxyethyl cellulose. Crosslinking was carried out with glutaraldehyde within aqueous droplets containing polymers mixture and maghemite, dispersed within toluene in presence of surfactants (Tween 80 and Span 80). The influence of the following preparation parameters on the physicochemical properties of the microparticles was studied: polymers mixture to maghemite weight ratio, gelatin to hydroxyethyl cellulose weight ratio and polymers mixture to crosslinking agent weight ratio. The particles were characterized for their morphology in terms of size distribution (laser diffraction analysis), and shape/surface aspects (scanning electron microscopy), magnetic properties (magnetisation), structure (Fourier transform infrared spectroscopy), chemical composition (Kjeldahl analysis and thermogravimetric analysis), loading and release of methotrexate, as antitumoral drug. The very low toxicity of these magnetic polymer microparticles makes them suitable for being used as drug carriers..

Keywords

Gelatin, Hydroxyethyl cellulose, Magnetic particles, Crosslinking, Controlled drug delivery.

Submitted at: July 12, 2012
Accepted at: Oct. 30, 2012

Citation

L. BALAITA, C. A. PEPTU, P. POSTOLACHE, G. LISA, M. POPA, Gelatin-hydroxyethyl cellulose magnetic microparticles as drug carriers: preparation and characterization, Journal of Optoelectronics and Advanced Materials Vol. 14, Iss. 11-12, pp. 1023-1033 (2012)