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Hybrid Chitosan-Gelatine magnetic polymer particles for drug release

L. BALAITA1,* , J. F. CHAILAN2, XUAN HOAN NGUYEN3, S. BACAITA1, M. POPA1

Affiliation

  1. “Gheorghe Asachi” Technical University of Iasi, Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, Prof.dr.docent Dimitrie Mangeron Street
  2. University of Sud Toulon-Var, ISITV, MAPIEM Laboratory (EA 4323), Avenue de l'Université – BP 56, 83162 La Valette du Var Cedex, France
  3. Faculty of Chemistry, VNU Hanoi University of Science 19 Le Thanh Tong, Hoan Kiem, Hanoi, Vietnam

Abstract

The chitosan-gelatin magnetic polymer nano/microparticles were synthesized by double crosslinking in reverse emulsion. In this method, sodium sulphate solution was added for ionic crosslinking and glutaraldehyde toluene extracted was added for covalent crosslinking of the polymers. The magnetite nanoparticles were synthesized by hydrothermal method and were used in the preparation process of magnetic polymer nano/microparticles as powder. The characterization of prepared magnetic polymer particles was performed by Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, laser diffraction analysis, Thermal Gravimetric Analysis and Vibrating Sample Magnetometry analysis. The in vivo acute toxicity of magnetic polymer particles was evaluated on rats. The swelling capacity in aqueous media of pH 7.4 and the ability to include and release 5-fluorouracil are influenced by the preparation parameters. The very low toxicity of these magnetic polymer particles makes them suitable for being used as potentials drug carriers..

Keywords

Crosslinking, Magnetite, Chitosan, Gelatin, Magnetic nanoparticles.

Submitted at: Dec. 18, 2013
Accepted at: Nov. 13, 2014

Citation

L. BALAITA, J. F. CHAILAN, XUAN HOAN NGUYEN, S. BACAITA, M. POPA, Hybrid Chitosan-Gelatine magnetic polymer particles for drug release, Journal of Optoelectronics and Advanced Materials Vol. 16, Iss. 11-12, pp. 1463-1471 (2014)