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Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications

L. BALAITA1,* , A. N. CADINOIU2, P. POSTOLACHE3, M. SAFARIKOVA4, M. POPA2

Affiliation

  1. Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 73 Prof. dr. docent Dimitrie Mangeron Blvd.,
  2. Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 73 Prof. dr. docent Dimitrie Mangeron Blvd.
  3. “Alexandru Ioan Cuza” University of Iasi, Faculty of Physics, 11 Carol I Blvd., 700506, Iaşi, România
  4. Department of Nanobiotechnology, Institute of Nanobiology and Structural Biology of GCRC, ASCR, Na Sadkach 7, 37005 Ceske Budejovice, Czech Republic

Abstract

This study was performed in order to obtain polymeric magnetic microparticles based on chitosan, poly(vinyl alcohol) and maghemite as colloidal magnetic nanoparticles. For preparation of particles we used double crosslinking in reverse emulsion procedure. Sodium sulphate (Na2SO4) solution is added for ionic crosslinking of the polymers and glutaraldehyde is used as covalent crosslinking agent. The following preparation parameters were studied: concentration of polymers solution, concentration of surfactants, poly(vinyl alcohol) to chitosan weight ratio, stirring speed, molar ratio between crosslinking agents, polymers to magnetic material weight ratio. The characterization of microparticles was performed by Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, Thermal Gravimetric Analysis and Vibrating Sample Magnetometry analysis. The evaluations of their toxicity together with hemocompatibility tests have shown that these particles exhibit the prerequisite behavior for use in biomedical field, for drug targeting. Also, was studied the behavior of particles in aqueous media, the drug (5-fluorouracil) loading and the kinetic of drug release from the particles, determined that particles behave differently depending on their structural characteristics, composition and morphology..

Keywords

Chitosan, Poly(vinyl alcohol), Magnetic particles, Ionic crosslinking, Covalent crosslinking, Drug delivery.

Submitted at: March 30, 2015
Accepted at: June 24, 2015

Citation

L. BALAITA, A. N. CADINOIU, P. POSTOLACHE, M. SAFARIKOVA, M. POPA, Magnetic polymer particles prepared by double crosslinking in reverse emulsion with potential biomedical applications, Journal of Optoelectronics and Advanced Materials Vol. 17, Iss. 7-8, pp. 1198-1209 (2015)