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New biocompatible materials by PVA / HC and biological polymers

F. CRIVOI1,* , L. STEFAN2, L. MOLDOVAN2, C. VASILE3

Affiliation

  1. “Gr. T. Popa”, Medicine and Pharmacy University, Physics Department, 16 University Street, Iasi, 700064, Romania
  2. National Institute of Research and Developing of Biological Sciences, 296 Splaiul Independentei Street, 6 Sector, 060031, Bucharest, Romania
  3. “P. Poni” Institute of Macromolecular Chemistry, Physical Chemistry of Polymers Laboratory, 41 A Gr. Ghica Voda Alley, Iasi, 700487, Romania

Abstract

This paper deals with obtaining and characterization of some bioartificial materials based on polyvinyl alcohol(PVA) with hydrolyzed collagen (HC) and small amounts of natural polymers such as: elastin (ELS), hyaluronic acid (HA) and chondroitin sulphate (CS). The film samples have been obtained by mixing of the solutions of polyvinyl alcohol and hydrolyzed collagen of 10 wt% concentration and the natural polymers in different proportions. By a complex of physicochemical, structural and biological methods such as SEM, DSC, thermogravimetry, IR-spectroscopy, MTT test, etc., the compatibility, interactions between components and cytotoxicity upon cells has been studied. On the basis of the obtained data can be concluded that all samples are compatible and the higher biocompatibility degree was recorded in the presence of glycosaminoglycans containing materials..

Keywords

Polyvinyl alcohol, Hydrolyzed collagen, Glycosaminoglycans, Blends, Compatibility, Cytotoxicity.

Submitted at: July 15, 2008
Accepted at: March 24, 2009

Citation

F. CRIVOI, L. STEFAN, L. MOLDOVAN, C. VASILE, New biocompatible materials by PVA / HC and biological polymers, Journal of Optoelectronics and Advanced Materials Vol. 11, Iss. 3, pp. 356-365 (2009)