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Preparation and characterization of new biocompatibilized polymeric materials for medical use

L. MOLDOVAN1, O. CRACIUNESCU1,* , O. ZARNESCU2, D. MACOCINSCHI3, D. BOJIN4

Affiliation

  1. National Institute of Research and Development for Biological Sciences, Department of Cellular and Molecular Biology, 296, Splaiul Independentei, sector 6, 060031, Bucharest, Romania
  2. Faculty of Biology, University of Bucharest, Romania
  3. “Petru Poni” Institute of Macromolecular Chemistry, Iassy, Romania
  4. BIOMAT Centre Bucharest, Romania

Abstract

The aim of this study was to prepare 4 new composite biomaterials based on polyurethane (PU) blended with different mixtures of collagen (COL), elastin (EL) and glycosaminoglycans (GAG). Bioactivated polymeric materials were structurally characterized by light and electron microscopy and their biodegradability and in vitro biocompatibility were comparatively assessed. The biomaterials presented smooth surfaces and the porosity decreased when natural polymers were added. All polymeric blend variants allowed cell proliferation and adhesion, with a more extensive growth on PU-COL variant. In conclusion, it was demonstrated that these new composite materials were biocompatible and good candidates for medical device fabrication..

Keywords

Biocompatibility, Biodegradability, Collagen, Elastin, Glycosaminoglycans, Polyurethane.

Submitted at: Nov. 13, 2007
Accepted at: April 4, 2008

Citation

L. MOLDOVAN, O. CRACIUNESCU, O. ZARNESCU, D. MACOCINSCHI, D. BOJIN, Preparation and characterization of new biocompatibilized polymeric materials for medical use, Journal of Optoelectronics and Advanced Materials Vol. 10, Iss. 4, pp. 942-947 (2008)