"

Cookies ussage consent

Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our site without changing the browser settings you grant us permission to store that information on your device.

I agree, do not show this message again.

Recent advancements in biomaterials and medical devices, aiming to improve consistently the outcomes of therapeutic approaches within spine/cord injury

G. ONOSE1,* , A. V.CIUREA2, R. E. RIZEA2, C. CHENDREANU1, A. ANGHELESCU1, M. HARAS1, F. BREHAR2, L. PADURE3

Affiliation

  1. Rehabilitation Department, Clinic Hospital “Bagdasar-Arseni”, 041915, Bucharest, Romania
  2. Neurosurgical Department, Clinic Hospital “Bagdasar-Arseni”, 041915, Bucharest , Romania
  3. The National Clinical Center for Pediatric Rehabilitation, 041408, Bucharest, Romania

Abstract

We emphasize some implantable “smart”, tissue engineering biomaterials and respectively, advanced devices, with important healing potential in spine and/or spinal cord injuries (SCI). There are two main types of such biomaterials: unresorbable and resorbable, separate in two distinct/ intricate cathegories: acellular and – more recent/ complex – construct scaffolds (polymeric/ gel-type, bioactive or/and self-assembling/ nano-processed). They serve as: continuity („filling the gap”)/holding (re)structures, intra-nevraxial neural (re)growth inhibitors’ blockers, contains, guides or/and stimulators for neo-forming tissues, delivery vehicles for cells and growth/neuro-protective factors, host immune attack/ reject reactions preventors, cell behavior controllers - including decrease of glial scar formation - or adjunct in bone grafting. Groundbreaking: molding “biological ink” (of micro-inkjet cell aggregates) into 3-D shaped biodegradable polymer gels, to build organs from the ground up (including inside repair/ regeneration). Related reliable trials are on going: they might, in the following about three years, eventually, show consistent improvements of SCI therapy outcomes..

Keywords

SCI, nevrax, “smart”/ tissue engineering biomaterials, Unresorbable / resorbable (gel-type) implants, Self-assembling/nano-processed scaffolds, “Biological ink”, Organ 3-D printing, Inside repair / regeneration, OFS, RPT.

Submitted at: Dec. 20, 2007
Accepted at: Jan. 18, 2008

Citation

G. ONOSE, A. V.CIUREA, R. E. RIZEA, C. CHENDREANU, A. ANGHELESCU, M. HARAS, F. BREHAR, L. PADURE, Recent advancements in biomaterials and medical devices, aiming to improve consistently the outcomes of therapeutic approaches within spine/cord injury, Journal of Optoelectronics and Advanced Materials Vol. 10, Iss. 1, pp. 18-28 (2008)