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Removal of interfering gases in breath biomarker measurements

A. M. BRATU1, C. POPA1, C. MATEI1, S. BANITA1, D. C. A. DUTU1, D. C. DUMITRAS1,*

Affiliation

  1. Department of Lasers, National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor St., PO Box MG-36, 077125, Bucharest, ROMANIA

Abstract

The analysis of exhaled breath has been proposed as a convenient and safe method for the routine monitoring of metabolic disorders. Exhaled breath may contain a variety of trace amounts of volatile organic compounds (VOCs): acetone, ethanol, ethylene, isoprene, methanol, pentane, etc. and several small inorganic molecules such as ammonia, nitric oxide, carbon oxide, carbon dioxide, etc. Many of these biomarkers have been detected using CO2 laser photoacoustic spectroscopy (LPAS). The measurement of the exhaled volatile hydrocarbons, such as ethylene (C2H4), a marker of oxidative stress in the human body, is a good noninvasive method to monitor lipid peroxidation. When low concentrations of ethylene have to be measured, it is necessary to remove CO2 (representing ~ 4% in exhaled breath sample) using a potassium hydroxide (KOH) scrubber. We investigated the efficiency of the KOH scrubber using four recipients with different volumes, and we found out that the concentration of CO2 in exhaled air can be reduced significantly only if a certain volume of scrubber is used..

Keywords

Breath analysis, Ethylene, Laser photoacoustic spectroscopy, Gas interference, KOH scrubber.

Submitted at: Aug. 4, 2011
Accepted at: Aug. 10, 2011

Citation

A. M. BRATU, C. POPA, C. MATEI, S. BANITA, D. C. A. DUTU, D. C. DUMITRAS, Removal of interfering gases in breath biomarker measurements, Journal of Optoelectronics and Advanced Materials Vol. 13, Iss. 8, pp. 1045-1050 (2011)