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MATVEY KANEVSKIY1, EKATERINA BORISOVA1,2,* , IRINA MIRONOVA1, SVETLANA KONNOVA1, ANNA GALITSKAYA1, ALEXANDER KHOROVODOV1, ILANA AGRANOVICH1, PETYA PAVLOVA3, LATCHEZAR AVRAMOV2, OXANA SEMYACHKINA-GLUSHKOVSKAYA1
- Saratov State University, 83, Astrakhanskaya str., 410012 Saratov, Russia
- Institute of Electronics, Bulgarian Academy of Sciences, 72, Tsarigradsko Chaussee Blvd., 1784, Sofia, Bulgaria
- Technical University - Sofia, branch - Plovdiv, 25, Tsanko Dyustabanov str., 4000 Plovdiv, Bulgaria
We studied gender differences in gastric tumor in rats using original model of gastric adenocarcinoma and photodiagnostics with delta-aminolevulinic acid, and impedance measurements of the stomach, liver and red blood cells in rats of both genders. Highly heterogeneous gastric adenocarcinoma in rats of both genders was induced by means of a prolonged exposure to social and chemical stresses. Exogenous fluorescence mapping using 5-aminolevulinic acid / protoporphyrin IX was performed on the developed tumors, and the suspicious areas were investigated and compared with the surrounding intact tissues by electrical bio-impedancemetry techniques. The histological data revealed significant gender differences in as the number of male rats with neoplasia was higher by a factor of 1.5. Exogenous fluorescence maps were detected in gastric cancerous areas, but no gender correlation was observed. Significant gender differences were revealed when bioelectrical impedance and polarization coefficients patterns were measured. In some cases, photodiagnosis yielded a false-positive exogenous fluorescence due to dye accumulation in benign and inflammatory mucosal areas and the application of additional methods, such as impedance measurement of gastric tissues and red blood cells might prove to be a promising way of improving the diagnostic efficiency of photodiagnosis, including gender-related aspects..
Chronic stress, Gastrointestinal cancer, Fluorescent detection, Tissue impedance.
Submitted at: Aug. 21, 2019
Accepted at: June 16, 2020
MATVEY KANEVSKIY, EKATERINA BORISOVA, IRINA MIRONOVA, SVETLANA KONNOVA, ANNA GALITSKAYA, ALEXANDER KHOROVODOV, ILANA AGRANOVICH, PETYA PAVLOVA, LATCHEZAR AVRAMOV, OXANA SEMYACHKINA-GLUSHKOVSKAYA, Stress-induced gastric adenocarcinoma: fluorescent and electrical measurements, Journal of Optoelectronics and Advanced Materials Vol. 22, Iss. 5-6, pp. 316-322 (2020)
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