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Studies on the preparation, characterization, solubility and stability of cefadroxil - β-cyclodextrin inclusion complexes

M. C. SHARMA1,* , S. SHARMA2

Affiliation

  1. School of Pharmacy, Devi Ahilya Vishwavidyalaya, Khandwa Road, Indore (M.P)-452001, India
  2. Department of Chemistry Yadhunath Mahavidyalya Bhind (M.P) - 477001 India

Abstract

Cefadroxil - β-Cyclodextrin dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Phase-solubility profile indicated that the solubility of Cefadroxil was significantly increased in the presence of β-cyclodextrin and was classified as AL-type, indicating the 1:4 stoichiometric inclusion complexes. Physical characterization of the prepared systems was carried out by differential scanning calorimetry (DSC), Xray diffraction studies (XRD) and IR studies. Solid state characterization of the drug β-CD binary system using XRD, FTIR and DSC revealed distinct loss of drug crystallinity in the formulation, ostensibly accounting for enhancement of dissolution rate..

Keywords

PH, Cefadroxil, Dissolution, β-cyclodextrin, Kneading method.

Submitted at: Feb. 12, 2010
Accepted at: Feb. 18, 2010

Citation

M. C. SHARMA, S. SHARMA, Studies on the preparation, characterization, solubility and stability of cefadroxil - β-cyclodextrin inclusion complexes, Journal of Optoelectronics and Advanced Materials Vol. 12, Iss. 2, pp. 411-415 (2010)