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Supramolecular organization of collagen and anti-cancer drugs

GH. TOMOAIA1, M. TOMOAIA-COTISEL2,* , A. MOCANU2, O. HOROVITZ2, L. D. BOBOS2, M. CRISAN1, I. PETEAN2

Affiliation

  1. Iuliu Hatieganu University of Medicine and Pharmacy, Orthopaedy, Traumatology and Dermatology Deptartment, T. Mosoiu Str., no. 47, 400132 Cluj-Napoca, Romania
  2. Babes-Bolyai University, Faculty of Chemistry and Chemical Engineering, Physical Chemistry Department, Arany J. Str., no. 11, 400028 Cluj-Napoca, Romania

Abstract

We have studied several biosystems comprising a fibrous protein, namely type 1 collagen (COL), which co-assembles with an anti-cancer drug, such as 5-fluorouracil (FLU) or doxorubicin (DOX), to form ordered films on glass or mica substrate, as visualized by atomic force microscopy. The anti-cancer drugs appear to lead to supramolecular collagen structures, with a remarkable nanoscale order, that mimics natural protein assemblies. Direct incorporation of such small molecules into the collagen assemblies represents a step toward rational design of nanostructured materials for a wide range of applications in synthetic biology and medicine, including the design of new drug delivery systems..

Keywords

Collagen, Fluorouracil, Doxorubicin, Self-assembly, AFM.

Submitted at: Nov. 13, 2007
Accepted at: April 4, 2008

Citation

GH. TOMOAIA, M. TOMOAIA-COTISEL, A. MOCANU, O. HOROVITZ, L. D. BOBOS, M. CRISAN, I. PETEAN, Supramolecular organization of collagen and anti-cancer drugs, Journal of Optoelectronics and Advanced Materials Vol. 10, Iss. 4, pp. 961-964 (2008)