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Thermal stability – singlet oxygen quantum yields relationship of some metallophtalocyanine sensitizers for photodynamic tests

S. F. POP1,2,* , R. M. ION1,2

Affiliation

  1. Department of Analysis, National Research & Development Institute for Chemistry and Petrochemistry ICECHIM, Spl. Independentei, 202, sect. 6, Bucharest, Romania
  2. Valahia University, Targoviste, 18-20 Blvd. Unirii., Targoviste, Romania

Abstract

Metallophthalocyanines (MPcs) have potential applications in many areas such as in medicine and material science [1]. Owing to their strong and long-wavelength absorption and efficient reactive oxygen specie generation (ROS) phthalocyanines have emerged as a promising class of second-generation photosensitizers for photodynamic therapy (PDT) [2]. Over the last decade, a substantial number of phthalocyanine-based photosensitizers have been prepared and evaluated for their photodynamic activity. In this work, the stability of metallophtalocyanine has been studied through thermogravimetry analysis, elemental analysis, quantum yields of singlet oxygen photogeneration and FT-IR analysis. Quantum yields of singlet oxygen photogeneration were determined in air (no oxygen bubbled) using the relative method with DPBF as chemical quencher for singlet oxygen [3.

Keywords

Phthalocyanine, Photodynamic activity, Thermal analysis, Singlet oxygen.

Submitted at: Aug. 6, 2010
Accepted at: Sept. 15, 2010

Citation

S. F. POP, R. M. ION, Thermal stability – singlet oxygen quantum yields relationship of some metallophtalocyanine sensitizers for photodynamic tests, Journal of Optoelectronics and Advanced Materials Vol. 12, Iss. 9, pp. 1976-1980 (2010)