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Vehicles of inverted hexagonal liquid crystalline lipid phases self-assembled at room temperature

B. ANGELOV1,* , A. ANGELOVA2, V. M. GARAMUS3, S. LESIEUR2

Affiliation

  1. Inst. of Macromol. Chemistry, Acad. Sci. Czech Rep., Heyrovskeho nam. 2, 16200 Prague, Czech Rep.,
  2. CNRS UMR8612 Institut Galien Paris-Sud, Univ Paris Sud 11, Châtenay-Malabry, France,
  3. Helmholtz-Zentrum Geesthacht, Centre for Materials and Coastal Research, 21502 Geesthacht, Germany

Abstract

Dispersed nonlamellar lipid phases offer one of the most important contemporary ways for the development of new materials for drug delivery vehicles. The structure of self-assembled vehicles of an inverted hexagonal type liquid crystalline (LC) lipid phase was investigated by means of small angle X-ray scattering (SAXS), quasi-elastic light scattering (QELS), and cross-polarised light optical microscopy (POM). A notable difference was established between the SAXS patterns of the bulk inverted hexagonal (HII) phase and the corresponding nanoparticles (NPs) dispersion. The structure of the hexosome NPs appeared to be more hydrated than that of the bulk HII phase. Both systems were stable at room temperature..

Keywords

liquid crystalline lipid nanoparticles, small angle X-ray scattering, cross-polarised light optical microscopy.

Submitted at: Jan. 29, 2013
Accepted at: April 11, 2013

Citation

B. ANGELOV, A. ANGELOVA, V. M. GARAMUS, S. LESIEUR, Vehicles of inverted hexagonal liquid crystalline lipid phases self-assembled at room temperature, Journal of Optoelectronics and Advanced Materials Vol. 15, Iss. 3-4, pp. 211-215 (2013)